Introduction: Melasma is a pigmentary disorder, generally difficult to treat, hence, the need for skin lightening agents. Recent studies found out that aloesin, a component of the aloe vera leaft extract, has a therapeutic effect on pigmentation suppression via its inhibitory effect on the tyrosinase activity.Based on these findings, aloe vera leaf extract may be used as an alternative treatment for melasma.

Objectives: The general objective of the study is to determine the efficacy and safety of aloe vera leaf extract in cream base for the clinical improvement of melasma among patients seen in Jose R. Reyes Memorial Medical Center, Dermatology Department, OPD

Methods: 35 patients (Fitzpatrick skin types III-V) diagnosed with epidermal or mixed type of melasma were given aloe vera extract in cream base to be applied over the hyperpigmented patches on the right malar area once a day. Similar cleansing soap and sunblock were given to the patients. Patient’s hyperpigmented patches, both treated and untreated, were evaluated at baseline and every 4 weeks using the Mexameter. This procedure was done for a period of 12 weeks.

Results: Based on the target of thirty five (35) subjects, this study came up with thirty one (31) respondents due to non-follow up of 4 patients. Skin melanin index on the right malar, as measured by a mexameter, decreased continuously and this reduction in pigmentation was statistically significant at 12 weeks of treatment (p=0.000). There was no incidence of adverse effects reported with the topical use of aloevera extract in cream base.

Conclusion: Aloe Vera Leaf Extract in cream base is an effective and safe alternative treatment option for the clinical improvement of melasma.