Journal of Geriatrics and Palliative Care

Research Article

Antiseptic, Antiperspirant and Deodorant Diaper for the Frail Older Adult with Urinary Incontinence

Elaine Wat1,2, Yan Ping Wang1,2, Helen Yau Tsz Chan1,2, Sally Wong1,2, Wing Hung Ko3, Patrick Hui4, Frency Ng4, Clara Bik San Lau1,2 and Ping Chung Leung1,2*

1Institute of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong
2State Key Laboratory for Research on Bioactivities and Clinical Application of Medicinal Plants, The Chinese University of Hong Kong, Hong Kong
3School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong
4Institute of Textiles and Clothing, Hong Kong Polytechnic University, China
*Address for Correspondence: Ping Chung Leung, Director, Centre for Clinical Trials on Chinese Medicine (CCTCM), The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, Tel: (852) 2252 8868, Fax: (852) 2632 5441; E-mail: pingcleung@cuhk.edu.hk
Submission: 23 May, 2019; Accepted: 05 September, 2019; Published: 10 September, 2019
Copyright: © 2019 Wat E, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction: Urinary incontinence is a common complaint among older people which could cause great burden to the carer and healthcare system. The idea of creating a special diaper for the older and frail older people suffering from urinary incontinence to prevent complications arising from over-night and persistent wetting of the perineal region therefore appear appealing and beneficial.
Aim of the study: The aim of this s tudy was to perform further laboratory studies to understand the sweat modulation effect of the herbal formula, and to determine whether the herbal formula and the herbal formula containing diaper would cause any skin toxicity.
Materials and Methods: In vitro studies including the Acetylcholinesterase (AChE) activity assay, and measurement of chloride efflux by short circuit current assay was performed to understand the sweat modulation effect of the herbal formula. In vitro skin toxicity test was also performed to determine whether the herbal formula and the herbal formula containing diaper would cause any skin toxicity.
Results: Our herbal formula containing Cortex Fraxini, Mori Follium and Calamine significantly increased the acetylcholinesterase activity in PC12 cells. This formula also significantly inhibited the UTP-evoked Cl- secretion and ACh-induced Cl- transport. Further skin toxicity test suggested this formula exerted no significant toxicity to the cells in the skin.
Conclusion: These data further supported the positive data observed in two clinical studies previously completed which demonstrated that the herbal formula could reduce sweat secretion, reduce odour, skin irritations and the herbal extract-containing diaper could improve the quality of life of individuals with urinary incontinence.