Journal of Andrology & Gynaecology

Research Article

Association between Stage and Degree of Differentiation with Ca-125 Levels and Inflammatory Response Markers in Malignant Serous Tumors of the Ovary

Kurban Y1 and Aslan F2

1Department of Obstetrics and Gynecology, Yuksek Ihtisas University Medicalpark Ankara Hospital, Turkey
2Department of Medical Oncology, Yuksek Ihtisas University Medicalpark Ankara Hospital, Türkey
*Address for Correspondence: Kurban Y, Department of Obstetrics and Gynecology, Yuksek Ihtisas University, Ankara Medical park Hospital, Kent Koop Mh. 06100. Batıkent / Yenimahalle / Ankara / Turkey, Tel: 905326872263; Email: drykurban@hotmail.com
Submission: 18 March, 2021; Accepted: 20 April, 2021; Published: 25 April, 2021
Copyright: © 2021 Kurban Y, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives: The present study aimed to assess the association between stage and degree of differentiation (grade), and levels of Ca-125 and neutrophil-to-lymphocyte ratio (NLR), as an inflammatory marker, in serous ovarian carcinoma.
Materials and Methods: A total of 71 patients with serous ovarian carcinoma, who were operated between 2016 and 2020 at the Ankara Medicalpark Batıkent Hospital, affiliated with the Yuksek Ihtisas University, were evaluated retrospectively. The retrospective evaluation included patients age, preoperative serum levels of Ca-125 and NLR. The patients were postoperatively staged based on the FIGO histopathological staging system and the degrees of differentiation as well as the status of lymph node involvement were recorded.
Results: The study participants had a mean age of 54.7 years, a mean Ca-125 level of 1199U/ml and a mean NLR of 5.8. The mean Ca- 125 level was 331, 724, 1186 and 2134 in stage I, II, III and IV patients, respectively, indicating an increase in Ca-125 levels with the increasing stage (p<0.001). The increased degree of differentiation (grade) was also significantly associated with Ca-125 levels. The higher the Ca- 125 level, the higher the tumor grade (p<0.001). The mean NLR was 3.28, 6.53, 6.73 and 6.76 in stage I, II, III and IV patients, respectively. There was an increase in NLR with increasing stage, and the difference was significant (p=<0.002). No significant difference was found in NLR between grades 1 and 2, while there was a significant difference between grades 1 and 3 (p< 0.001).
Conclusion: The levels of Ca-125 and NLR were associated with an increased degree of differentiation and stage in epithelial malignant serous ovarian tumors.