Journal of Orthopedics & Rheumatology

Research Article

Cartilage Tissue Engineering: An Update on Multi-Component Approach

Zong Z1, Wu X1,2, Su Z1, Wang Z1, Zhao Z1, Huang J3, Zhong C4, Wei B1, Li G5 and Lin S1,2,6*

1Orthopaedic Center, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, China
2Marine Biomedical Research Institute, Guangdong Medical University, China
3Department of Stomatology, Guangdong Medical University, China
4Institute of Laboratory Medicine, Guangdong Medical University, China
5Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, China
6Department of Orthopaedic Surgery, Stanford University, USA
*Address for Correspondence: Lin S, Department of Orthopaedic Surgery, School of Medicine, Stanford University, 300 Pasteur Drive, Edwards R163, Stanford, CA 94305, USA; E-mail: sienlin@stanford.edu
Submission: 08 November 2019; Accepted: 05 December 2019; Published: 12 December 2019
Copyright: © 2019 Zong Z, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cartilage injury and osteoarthritis are big clinical challenges as self-healing potential of cartilaginous tissue is very limited. The need for a multi-disciplinary approach in order to establish new strategies for cartilage healing has been addressed by many scientists from the fields of orthopaedic surgery or biomedical engineering in the last two decades. With a focus on the very preclinical research in this field, this review covers the multitude of approaches, ranging from cell-based to scaffold-based strategies and also including growth factors, precondition approach, mechanical stimulation-that have been combined to assess their potential to develop effective concepts for the treatment of cartilage injury or osteoarthritis.