Journal of Orthopedics & Rheumatology
Research Article
Cartilage Tissue Engineering: An Update on Multi-Component Approach
Zong Z1, Wu X1,2, Su Z1, Wang Z1, Zhao Z1, Huang J3, Zhong C4, Wei B1, Li G5 and Lin S1,2,6*
1Orthopaedic Center, Affiliated Hospital of Guangdong Medical
University, Guangdong Medical University, China
2Marine Biomedical Research Institute, Guangdong Medical University, China
3Department of Stomatology, Guangdong Medical University, China
4Institute of Laboratory Medicine, Guangdong Medical University, China
5Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, China
6Department of Orthopaedic Surgery, Stanford University, USA
2Marine Biomedical Research Institute, Guangdong Medical University, China
3Department of Stomatology, Guangdong Medical University, China
4Institute of Laboratory Medicine, Guangdong Medical University, China
5Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, China
6Department of Orthopaedic Surgery, Stanford University, USA
*Address for Correspondence: Lin S, Department of Orthopaedic Surgery, School of Medicine, Stanford
University, 300 Pasteur Drive, Edwards R163, Stanford, CA 94305, USA; E-mail: sienlin@stanford.edu
Submission: 08 November 2019;
Accepted: 05 December 2019;
Published: 12 December 2019
Copyright: © 2019 Zong Z, et al. This is an open access article
distributed under the Creative Commons Attribution License, which
permits unrestricted use, distribution, and reproduction in any medium,
provided the original work is properly cited.
Abstract
Cartilage injury and osteoarthritis are big clinical challenges as
self-healing potential of cartilaginous tissue is very limited. The need
for a multi-disciplinary approach in order to establish new strategies
for cartilage healing has been addressed by many scientists from the
fields of orthopaedic surgery or biomedical engineering in the last two
decades. With a focus on the very preclinical research in this field,
this review covers the multitude of approaches, ranging from cell-based
to scaffold-based strategies and also including growth factors,
precondition approach, mechanical stimulation-that have been
combined to assess their potential to develop effective concepts for
the treatment of cartilage injury or osteoarthritis.