Journal of Orthopedics & Rheumatology

Research Article

Validation of Incorporating Standardized Formula with Phytoconstituents in Knee Osteoarthritis: A Randomized, Placebo-Controlled Study

Shridhar Pandya1, Chetan Savaliya2, Amol Gothwad3, Tanuja Panchabhai4, Gayatri Ganu5 and Dheeraj Nagore6*

1Director, Gplife Healthcare Pvt Ltd, 705-706, Orbit- 1 Building, Punagam-Saroli Rd, Near RRTM Market, Surat, 395010, India
2Director, Gplife Healthcare Pvt Ltd, 705-706, Orbit- 1 Building, Punagam-Saroli Rd, Near RRTM Market, Surat, 395010, India
3Consultant, Lokmanya Medical Research Centre Lokmanya Hospital, Floor 4, OPD 1, 314/B Telco Road, Chinchwad, Pune, 411033 Maharashtra, India
4Consultant, Atharv multispecialty Research center, Krishna chowk, Kirti Nagar, New Sanghavi, Pune 411027 Maharashtra, India.
5Director, Mprex Healthcare Pvt Ltd, 501, 514, Crossroads building, Bhumkar Chowk, Wakad, Pune 411057, India
6Director, Mprex Healthcare Pvt Ltd, 501, 514, Crossroads building, Bhumkar Chowk, Wakad, Pune 411057, India
*Address for Correspondence: Dr. Dheeraj Nagore, Mprex Healthcare Pvt Ltd, 501, Crossroads building, Bhumkar Chowk, Wakad, Pune 411057, India. Email: dheeraj@mprex.in
Submission: 19 October 2022
Accepted: 08 February 2023
Published: 13 February 2023
Copyright: © 2023 Pandya S, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background: Osteoarthritis (OA) is the most common joint disease with a prevalence of 22% to 39% in India and being foremost causes of nonfatal burden. The use of conventional medication can be associated with insufficient clinical management, serious side effects. The present research validates using Joint Support Product (JSP) a standardized, specially designed herbal extract-based formula with phytonutrients which are useful in the management of symptoms as well as regeneration in OA.
Method: Clinical trial was randomized placebo-controlled involving 150 patients with knee osteoarthritis included in two parallel groups equally. JSP and placebo were provided for 90 days. The celecoxib tablets up to 200 mg as rescue was allowed and recorded. The objectives of the study were to assess the effectiveness and safety of JSP in osteoarthritis by evaluating pain, stiffness, symptoms and antiinflammatory activity to improve quality of life.
Results: Treatment of JSP in patients with osteoarthritis led to reduction in pain, stiffness and other related parameters to provide the symptomatic relief and thus improved quality of life. Treatment with JSP reduced the inflammatory markers by 50% suggestive potential joint restorative action. With JSP, most of the subjects showed reduced dependency on the analgesics as a rescue. There were no evident side effects of the JSP treatment.
Conclusion: It can be concluded from the study that JSP is safer and effective option in the management of OA. With treatment with JSP, most of the subjects showed reduced dependency on the analgesics as a rescue in the treatment tenure.