The inability of couples of reproductive age women to conceive after a year of regular sexual Intercourse is term infertility. Hormonal abnormality of the hypothalamic-pituitary- gonadal axis is one of the cause of infertility. Thus, the measurement of peptide and steroid hormones in serum is an essential aspect of the evaluation of infertility.

Method: This is a retrospective study of gonadotropin disorder of 268 reproductive age women between 20-45 years and with infertility duration between 2-7 years, who attended fertility clinics at the Delta State University Teaching Hospital, Oghara, Delta State, Nigeria between 2015-2020.

Results: The mean age of 268 reproductive age women is 33.50 ± 5.3 which accounts for 85.5 % menstruating while 14.5 % non- menstruating and with infertility duration of 2 to 7 years. Hypergonadotropic hypogonadism accounts for12.3 % with mean FSH, LH, Progesterone of 48.39±31.28, 30.91±-16.4, 0.34±0.14, p-value ,0.05 while hypogonadotropic hypogonadism accounts for 2.2 % with mean FSH, LH of 0.62±0.56, 0.46± 0.5, p-value .>0.05 and progesterone of 0.33 ±0.22 with p-value <0.04. In addition, isolated FSH group account for the functional gonadotropin secreting tumors which represent 11.6% and mean FSH, LH values of 15.55±8.6, 6.84±2.4 with p-value of < 0.05. Also, normal gonadotropins group accounts for 73.9% with a mean for FSH, LH of 5.61±1.5, 5.16±2.2 and with p-value <0.05.

Conclusion: One of the causes of infertility among reproductive age women in this study are hypergonadotropic hypogonadism, hypogonadotropic hypogonadism and gonadotropin secreting adenomas which accounts for 26.1 % of gonadotropins disorder and this findings need early intervention by the clinical team in our setting.