Journal of Pediatrics & Child Care
Case Report
Hypertriglyceridemia Induced By L-Asparaginase and Prednisolone in Pediatric Hemato-Oncology: A Case Report
Goutham KJ2, Swathi J3, Nishit3, Deepti A2, Harika V2, Rekha B2, Priyank T2, Roshini DG3, Hanan P2, Anjali M3, Amey P3 and Sachin SJ1
1Hematology & SCT, HCG Cancer Hospital, Bangalore, India
2Clinical Pharmacology, HCG Cancer Hospital Bangalore, India
3Consultants, HCG Cancer Hospital, Bangalore, India
*Address for Correspondence:
Sachin SJ, Hematology & SCT, HCG Cancer Hospital,
Bangalore, India; Phone: 9741351357; E-mail: drsachin.
jadhav@hcgel.com
Submission: 11 May, 2022
Accepted: 24 June, 2022
Published: 29 June, 2022
Copyright: © 2022 Goutham KJ, et al. This is an open access
article distributed under the Creative Commons Attr-ibution
License, which permits unrestricted use, distribution, and
reproduction in any medium, provided the original work is
properly cited.
Abstract
Introduction: L-asparaginase and corticosteroids are widely used
in the chemotherapy of acute lymphoblastic leukemia (ALL). This
combination is known to cause several adverse effects one of which
is hypertriglyceridemia. Although the condition is asymptomatic and
reversible it can lead to serious complications.
Case description: This case report of 2-years 6 months old Indian
male baby who was on treatment for ALL on day 41 triglycerides levels
were 3324mg/dL with no significant symptoms, it was well managed,
and the triglyceride levels drop down to 117mg/dL without any
complications and interruption in the ongoing treatment.
Conclusion: Combination therapy of L-asparaginase and steroids
cause hypertriglyceridemia through various mechanisms leading to
various life-threatening complications. However, there are no standard
guidelines available to treat drug induced hypertriglyceridemia.
Frequent monitoring of serum levels may aid in early diagnosis,
prevents complications.