Journal of Veterinary Science & Medicine

Research Article

Investigation of Antiviral Effect of Far-UVC Microplasma Lamp against Influenza A Virus (H9N2)

Do HQ1, Park YH2, Kim SS3, Lee J4, Jung WK2* and Chung HC5,6*

1Department of Veterinary Medicine Virology Lab, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University GwanAk-Ro 1, GwanAk-Gu, Seoul 151- 742, South Korea
2NoAH Biotech Co., Ltd., Suwon 16614, South Korea
3NANOCMS Co., Ltd., Cheonan 31040, South Korea
4Computational Neurobiology Laboratory, Salk Institute of Biological Sciences, La Jolla, CA 92037
5Department of Microbiology and Immunology, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, South Korea
6Department of General Medicine, International European University, Nieszawska 19, 61-021 Poznań, Poland
*Address for correspondence: Jung WK, NoAH Biotech Co., Ltd., Suwon 16614, South Korea; Email: wkj@noah-biotech.com; Phone: +82-31-292-1257
Chung HC, Department of Microbiology and Immunology, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, South Korea & Department of General Medicine, International European University, Nieszawska 19, 61-021 Poznań, Poland; E-mail: heeskyi@yuhs.ac; Phone: +82-2-2228-1836
Submission: 15 September, 2022
Accepted: 17 October, 2022
Published: 19 October, 2022
Copyright: © 2022 Do HQ, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Influenza A virus is one of the most serious diseases in the world. Therefore, it is necessary to find an effective and safe method to prevent the spread of the disease. A far-UVC at 222nm is considered safe and effective for viral and bacterial treatment. In this study, virucidal effects and the safety status of far-UVC microplasma were evaluated in vitro against influenza A virus H9N2 0130 strain. The results (from TCID50 and real-time PCR) indicated that a far-UVC inhibited influenza A virus depending on dosage. A far-UVC eliminated 99.99% of the virus at doses of 44 and 56 mJ/cm2 in clarified and un-clarified solutions, respectively. Moreover, a far-UVC 222 nm did not have any harmful effects in MDCK cell at dose 78 mJ/cm2. Our study provided useful information in a far-UVC application against influenza A virus.