Journal of Veterinary Science & Medicine

Research Article

Investigation of In-Vivo Effect of St. John’s Wort (Hypericum Perforatum) In Lung Cancer

Aktaş S*, Erol A, Serinan EO, Gökbayrak OE and Altun Z

Department of Basic Oncology, Institute of Oncology, Dokuz Eylul University, Izmir, Turkey
*Address for correspondence: Aktaş S, Department of Basic Oncology, Institute of Oncology, Dokuz Eylul University, Izmir, Turkey; Email: safiyeaktas@gmail.com
Submission: 7 July, 2021; Accepted: 10 August, 2021; Published: 15 August, 2021
Copyright: © 2021 Aktaş S et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Due to limitations in the treatment of lung cancer, finding natural compounds from plants can provide an alternative treatment for lung cancer. St. John’s Wort (SJW) has anti-proliferative and pro-apoptotic properties that can be used in lung cancer treatment. The aim of this study is to explore antitumor effect of SJW in lung cancer in vivo animal model. 35 animals; 7 animals in each group were randomized as control, Doxorubicin, SJW early treatment, SJW treatment, and doxorubicin+SJW groups. After 7 days sacrification was performed. Tumor diameter did not show statistically significant change but in all four-group compared with control group; tumor tissue showed prominent necrosis and apoptosis. No histologic changes observed in other tissues. Biochemistry did not show organ insufficiency.
SJW is shown to have antitumoral effect in subcutaneous xenograft lung cancer in vivo model in nude mice. Dose was obtained comparing with DOX. In combination with DOX, there were no synergistic increase in anti-tumo effect. SJW might be a candidate antineoplastic supplementation in lung cancer.