Journal of Veterinary Science & Medicine
Research Article
Investigation of In-Vivo Effect of St. John’s Wort (Hypericum Perforatum) In Lung Cancer
Aktaş S*, Erol A, Serinan EO, Gökbayrak OE and Altun Z
Department of Basic Oncology, Institute of Oncology, Dokuz Eylul University, Izmir, Turkey
*Address for correspondence:
Aktaş S, Department of Basic Oncology, Institute of Oncology, Dokuz
Eylul University, Izmir, Turkey; Email: safiyeaktas@gmail.com
Submission: 7 July, 2021;
Accepted: 10 August, 2021;
Published: 15 August, 2021
Copyright: © 2021 Aktaş S et al. This is an open access article
distributed under the Creative Commons Attribution License, which
permits unrestricted use, distribution, and reproduction in any medium,
provided the original work is properly cited.
Abstract
Due to limitations in the treatment of lung cancer, finding natural
compounds from plants can provide an alternative treatment for lung
cancer. St. John’s Wort (SJW) has anti-proliferative and pro-apoptotic
properties that can be used in lung cancer treatment. The aim of
this study is to explore antitumor effect of SJW in lung cancer in vivo
animal model. 35 animals; 7 animals in each group were randomized
as control, Doxorubicin, SJW early treatment, SJW treatment, and
doxorubicin+SJW groups. After 7 days sacrification was performed.
Tumor diameter did not show statistically significant change but in
all four-group compared with control group; tumor tissue showed
prominent necrosis and apoptosis. No histologic changes observed in
other tissues. Biochemistry did not show organ insufficiency.
SJW is shown to have antitumoral effect in subcutaneous xenograft
lung cancer in vivo model in nude mice. Dose was obtained
comparing with DOX. In combination with DOX, there were no
synergistic increase in anti-tumo effect. SJW might be a candidate
antineoplastic supplementation in lung cancer.