Advances in Diabetes & Endocrinology

Research Article

Microalbuminuria in Type 2 Diabetes and its Relationship with Glycosylated Hemoglobin

Ferdousi S1, Nasreen T2, Md. Islam S1, Md. Rahman Q1, Selim S3, Paul D1, Ahmed MU4* and Sultana T1

1Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University, Bangladesh
2Transfusion Medicine and Clinical Haematology Department, BIRDEM General Hospital, Bangladesh
3Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Bangladesh
4Masters in Microbiology, Bangladesh University of Professionals, Bangladesh
*Address for Correspondence: Ahmed MU, Masters in Microbiology, Bangladesh University of Professionals, Dhaka, Bangladesh
Submission: 20 April, 2018 Accepted: 01 October, 2019 Published: 04 October, 2019
Copyright: © 2019 Ferdousi S, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background: Microalbuminuria is the most common aetiology of chronic kidney disease. Optimum glycemic control reduces the development and progression of diabetes-related complications and there is evidence that improved glycemic control improves outcome in diabetic subjects.
Objective: This study was designed to know the relationship of glycosylated hemoglobin (HbA1c) level with microalbuminuria and normoalbuminuria in type 2 diabetic patients and its relation to diabetic nephropathy. Materials and methods: This study was conducted at the Department of Laboratory Medicine (Clinical Pathology) in collaboration with Endocrinology department (BSMMU), Dhaka. In this study, HbA1c level and urine microalbumin level of 60 type 2 diabetic patients were measured. Both levels were measured by biochemical auto analyzer (Siemens Dimension RL Max).
Results: Urinary microalbumin, HbA1c levels were significantly higher in the cases. Microalbumin levels were linearly correlated to the duration of diabetes and HbA1c.
Conclusion: Impaired glycemic control is associated with significant elevations in urinary microalbumin levels. Furthermore, there is an increased urinary microalbumin levels with increased duration of diabetes, which suggests that the detection of increased urinary microalbumin levels at the initial stage can avert, reduce the clinical and economic burden of diabetic complications in future.