Journal of Human Anatomy & Physiology
Review Article
miR-24 and its Role as an Oncogene in Cancer
Rivas-Alarcón A, Organista-Nava J, Illades-Aguiar B, Leyva-Vázquez MA* and Gómez-Gómez Y*
Laboratorio de Biomedicina Molecular, Facultad de Ciencias Químico-Biologicas, Universidad Autonoma de Guerrero, Chilpancingo, Guerrero, Mexico
*Address for Correspondence: Gomez-Gomez Y, Laboratorio de Biomedicina Molecular, Facultad de Ciencias Quimico-Biologicas, Universidad Autonoma de Guerrero, Chilpancingo, Guerrero, Mexico; E-mail: yazmigomezgomez@gmail.com Leyva-Vazquez MA, Laboratorio de Biomedicina Molecular, Facultad de Ciencias Químico-Biologicas, Universidad Autonoma de Guerrero,
Chilpancingo, Guerrero, Mexico E-mail: leyvamarco13@gmail.com
Submission date: 01 March, 2019;
Accepted date: 29 July, 2019;
Published date: 01 August, 2019
Copyright: © 2019 Rivas-Alarcón A, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
MicroRNAs (miRNAs) regulate the expression of genes involved in numerous cellular processes, including proliferation, metabolism, differentiation and apoptosis. Changes in the expression levels of miRNAs are associated with the development of various diseases, including cancer. Dysregulation of miRNA expression has been demonstrated to have a role in tumorigenesis and it has been revealed that some miRNAs can act either as oncogenes or tumor suppressors in cancer. miRNA-24 has been identified as an oncogene in various types of cancer. This review discusses the function of miRNA-24 as oncogene in gastric cancer, breast cancer, pancreatic cancer, lung cancer and leukemia.