Journal of Surgery

Review Article

Role of Wall Shear Stress in an Intracranial Aneurysm Formation: A Systematic Review

Neupane D1*, Lageju N1, Dahal A2, Jaiswal LS3, Manandhar S1, Chhetri S1, Acharya R1, Pokhrel N1 and Panthi S1

1Department of Surgery, B. P. Koirala Institute of Health Sciences, Dharan, Nepal.
2Division of Neurosurgery, B. P. Koirala Institute of Health Sciences, Dharan, Nepal.
3Division of CTVS, B. P. Koirala Institute of Health Sciences, Dharan, Nepal
*Address for Correspondence Neupane D, Department of Surgery, B. P. Koirala Institute of Health Sciences, Dharan, Nepal; E-mail: neupanedurga26@gmail.com
Submission: 06 June, 2022
Accepted: 25 July, 2022
Published: 29 July, 2022
Copyright: © 2022 Neupane D, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background: Recent evidence suggests a link between hemodynamic factors and intracranial aneurysm inception. However, the role of wall shear stress is not clearly understood.
Aim: To elucidate the role of wall shear stress in intracranial aneurysm formation.
Methods: We performed areview of literature by recruiting articles from 2000 through 2019. 2134 unique articles were identified, of which 32 were retrieved for more detailed evaluation. 17 articles met the inclusion criteria and were involved in the qualitative analysis. Standard guidelines were followed.
Results: Wall shear stress showed to have a significant role in intracranial aneurysm inception. Other hemodynamic factors also played role in the inception of cerebral aneurysms. The geometry and optimality principle along with social factors like smoking is also responsible for the formation of cerebral aneurysms.
Conclusion: Wall shear stress plays a major role in intracranial aneurysm formation. Gradient oscillatory number is the emerging hemodynamic factor for the inception of cerebral aneurysms. However, limited experiments in humans have resulted in inconclusive results.