Journal of Vaccine & Immunotechnology
Review Article
Study of Genetic Mutations in Gene ZAP70 in Inducate ZAP70-Related Severe Combined Immuno Deficiency Syndrome
Shahin Asadi*
Department of Medical Genetics, Molecular Medicine Genetics Harvard University, Iran
*Address for Correspondence: Shahin Asadi, Department of Medical Genetics, Molecular Medicine Genetics Harvard University, Director of the Division of Medical Genetics and Molecular Research, Division of Medical Genetics and Molecular Pathology Research, Massachusetts, Iran, E-mail:
shahin.asadi1985@gmail.com
Submission: 02 March, 2019;
Accepted: 03 April, 2019;
Published: 05 April, 2019
Copyright: © 2019 Asadi S, et al. This is an open access article
distributed under the Creative Commons Attribution License, which
permits unrestricted use, distribution, and reproduction in any medium,
provided the original work is properly cited.
Abstract
ZAP70-SCID syndrome is a hereditary genetic disorder that
damages the immune system. Children with SCID have virtually no
immune system against bacterial, viral, and fungal infections. SCID is
a group of very rare, life-threatening diseases that are present at birth.
The disease causes the child to have very little or no immune system.
As a result, the child’s body is unable to fight off infections. This disease
process is also known as the “boy in the bubble” syndrome because
living in the normal environment can prove fatal to these children.
Children with this rare, inherited disease become very ill with
illnesses such as pneumonia, meningitis, and chickenpox and can
die within the first year of their life. With new advances in treatments,
however, children with SCID can be successfully treated.
ZAP70-SCID syndrome is caused by the mutation of the ZAP70
gene, which is based on the long arm of chromosome number 2 as
2q11.2.