Starting from dozens of studies on neural correlates during mystical experiences and the use of extrasensory skills from the common sense, I proceeded to contextualize in a more scientific way the concept of extrasensory mediums and faculties, then analyzing the state of the art in relation to discoveries in the neuro scientific field concerning precisely the alleged extrasensory faculties possessed and the perception of the sacred in the subjects of the researches so far evaluated. From this examination there emerges a direct involvement of the cerebral areas of the frontal and temporal lobes and in general of the circuits connected to the limbic system. This thematic research has deepened the object of study concerning the phenomena of subjective perception; however, in the last part I proceeded instead to suggest a research-oriented research scheme not so much of the subjective profiles already known as much as the hypothesis of the existence of the entities perceived by the mediums, therefore an objective profile, in order to better know the external context of the medium.