Journal of Pharmaceutics & Pharmacology
Review Article
The Sars-Cov-2 Viroporin E and its Interaction with Amantadine an Analysis
Aranda-Abreu GE*, Hernández-Aguilar ME, Herrera-Covarrubias D and Rojas-Durán F
Universidad Veracruzana/Centro de Investigaciones Cerebrales, México
*Address for Correspondence:
Aranda-Abreu GE, Universidad Veracruzana/Centro de Investigaciones
Cerebrales, Xalapa, Veracruz, México; E-mail: garanda@uv.mx
Submission: 14 August 2020;
Accepted: 15 September 2020;
Published: 21 September 2020
Copyright: © 2020 Aranda-Abreu GE, et al. This is an open access
article distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any
medium, provided the original work is properly cited.
Abstract
This article discusses the function of the SARS-Cov-2 virus E-channel
and its interaction with amantadine.In this analysis it is proposed that
amantadine is able to enter the E-channel of the coronavirus, inhibiting
the viral content to enter the cell avoiding viral replication. Therefore,
amantadine is a drug that can help decrease the symptoms of
coronavirus. It is also mentioned how amantadine may be acting with
the Spike protein, through a molecular docking study.