The recent history of gonorrhea treatment in Russia is discussed here after 2 case histories. Methods of topical treatment and provocation, not used in other countries, are described. Being informed of the lengthy and unpleasant therapy, risk groups avoided dermatovenereological dispensaries (prevention and treatment centers) and practiced self-treatment, which contributed to the spread of sexually transmitted infections. However, it is early to completely discard the topical therapy. The antimicrobial resistance is developing. One of the contributing factors is the use of antibiotics as cattle feed additives and food preservatives