Effective management of dry skin conditions involves the treatment of a defective skin barrier. Moisturizers enhance and preserve the smoothness of the skin in patients with dry skin conditions as well as those with healthy skin. Many ingredients of moisturizers have the potential to cause irritant and allergic contact dermatitis; therefore, it is necessary for clinicians to be aware of such potential allergens to manage and advise their patients’ accordingly. Moisturizers free of paraben, mineral oil, alcohol and ingredients from animal origin (PAMA) have an advantage since they don’t cause sensitivity, allergy or dermatitis. This review will help dermatologists understand the need and benefits of low allergen containing moisturizers.